- National Technology Centre for Ports, Waterways and Coasts (NTCPWC)
- Robert Bosch Center for Data Science and Artificial Intelligence
- Centre of Excellence on Dam Safety & Dam Rehabilitation
- Centre of Excellence (CoE) in Advanced Materials and Manufacturing
- Centre of Propulsion Technology (CoPT)
- Graphene Applications (TSAMRC)
- The Centre for Excellence in Steel Technology (CoExiST)
- Industrial Internet of Things (IIT-GE)
- for Urbanization, Buildings and the Environment (CUBE)
- Applied Centre for Advanced Automotive Research (CAAR)
- Indian Solar Energy Harnessing Centre (ISEHC)
- Raghupathi Singhania Centre of Excellence for Tyre & Vehicle Mechanics
- Centre of Excellence in Urban Transport
- Centre of Decentralised Power Systems
- Centre for Non-Destructive Evaluation
- National Centre for Combustion R&D
- National Centre for Catalysis Research
- Centre for NEMS & Nanophotonics (CNNP)
- Healthcare Technology Innovation Centre( HTIC)
- Centre for Technology and Policy (CTaP)
- National Centre for Safety of Heritage Structures (NCSHS)
- Indo-German Centre for Sustainability (IGCS)
- China Studies Centre
- Reliance-IITM Telecom Centre of Excellence
- Centre for Functional Nanomaterials
- Thematic Unit of Excellence on Water
- Centre for Excellence in Wireless Technology (CEWIT)
- Centre of Excellence on Machine Tools and Production Technology (AMTDC)
- Centre of Excellence in Iron & Steel Technology (COEXIST)
- Centre for Computational Brain Research (CCBR)
- Interdisciplinary Laboratory in Data Sciences (ILDS)
- Initiative in Biological Systems Engineering (IBSE)
- Centre for Social Innovation & Entrepreneurship (CSIE)
- Centre for Railway Research (CRR)
- Centre for Battery Engineering and Electric Vehicles (CBEEV)
- TTK Centre for Rehabilitation Research and Device Development (R2D2)
- Thematic Unit of Excellence (TUE) on Water Purification using Nanotechnology